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  3. Animal studies are under way, human trial protocols are taking shape and drug makers are on alert. All the international health

Animal studies are under way, human trial protocols are taking shape and drug makers are on alert. All the international health

admin2014-06-13  94
问题     Animal studies are under way, human trial protocols are taking shape and drug makers are on alert. All the international health community needs now is a human vaccine for the bird flu pandemic sweeping a cluster of Asian countries.
    The race for a vaccine began after the first human case emerged in Hong Kong in 1997. Backed by the World Health Organization (WHO), three research teams in the US and UK are trying to create a seed virus for a new vaccine. Their task is formidable, but researchers remain optimistic". There are obstacles, but most of the obstacles have been treated sensibly", says Richard Webby, a virologist at St. Jude Children’s Research Hospital in Memphis, Tennessee.
    The biggest challenge is likely to be the rapidly mutating virus. Candidate vaccines produced last year against the H5N1 virus are ineffective against this year’s strain. Scientists will have to constantly monitor the changes and try to tailor the vaccine as the virus mutates. They can’t wait to see which one comes next.
    The urgency stems from fears that H5N1 will combine with a human flu virus, creating a pathogen(病原体) that could be transmitted from person to person. But if people have no immunity to the virus, the strain may not mutate as rapidly in people as it does in birds.
    To quickly generate the vaccine, researchers are using reverse genetics, which allows them to skip the long process of searching through reassorted viruses for the correct genetic combination. Instead, scientists clone sequences for hemagglutinin(红血球凝聚素) and neuraminidase(神经氨酸苷酶), the two key proteins in the virus. The sequences are then combined with human influenza genes to create a customized reference strain.
    Because products developed with reverse genetics have never been tested in humans, the candidate vaccines will first have to clear regulatory review. In anticipation, the US Food and Drug Administration (FDA) and the European Agency for the Evaluation of Medicinal Products (EMEA) are both preparing pandemic response plans. The EMEA has produced a fist-track licensing program, an industry task force and detailed guidance for potential applicants.
    In Europe, a reassortant influenza virus—but not the inactivated vaccine—produced by reverse genetics would be considered a genetically modified organism, and manufacturers would need approval from their national or local safety authorities. The WHO has prepared a preliminary biosafety risk assessment of pilot-lot vaccine, which could help speed up the review.
    A preliminary version of their protocol calls for several hundred subjects, beginning with a group of young adults and gradually expanding to include those most susceptible to the flu—children and the elderly". If we had product", says Lambert", it would probably be a couple of months at the earliest before we have early data in healthy adults".
选项 A、flinch from their work.
B、hesitate and feel perplexed.
C、carry on their research.
D、abandon their research.
答案C
解析 为细节理解题。文章第二段中间提到："尽管科研工作者的任务艰巨，但是他们还是保持乐观的工作态度"。所以我们可以排除A：逃避工作；和B：犹豫以及迷茫，这两个选项。D选项的后半段说"放弃了研究"，正好相反，他们并没有放弃，所以也是不确的。因此正确答案是C。
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