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  3. The Great Lyme Debate There’s a debate raging over Lyme disease, although you’d never know it unless you’ve been paying clos

The Great Lyme Debate There’s a debate raging over Lyme disease, although you’d never know it unless you’ve been paying clos

admin2011-06-24  61
问题     The Great Lyme Debate
    There’s a debate raging over Lyme disease, although you’d never know it unless you’ve been paying close attention—because on the surface it sounds like the dullest argument imaginable. Last year, the Infectious Diseases Society of America issued new guidelines saying physicians should treat Lyme with antibiotics for no longer than 30 days. Some docs think that’s wrong. It’s a seemingly straightforward difference of opinion. So why has the debate dissolved into animosity, with one side suggesting that its opponents have no credibility and the other slinging deeply personal insults on the Web? And why has it now spilled out of medical journals and onto the office of a state attorney general? Clearly, something other than ticks is bugging a lot of doctors.
    Lyme disease—the most common insect-borne ailment in America, with roughly 20,000 cases diagnosed each year and more undetected—is transmitted mostly by a well-known pest, the deer tick. But the real culprit is something even nastier, a bacterium called Borrelia burgdorferi that lives in the tick’s gut. When Borrelia infiltrates the human body, it can cause a suite of distinctive symptoms, most notably a flulike feeling and a red rash like a bull’s-eye. Sometimes, though, it causes no symptoms at all, and that’s more dangerous, because the early signs are the only warnings doctors have. If Lyme is left undiagnosed and untreated, its consequences can be serious, including arthritis, meningitis, heart problems and inflammation of the brain. "The real secret," says Dr. Michael Zimring, director of the Center for Wilderness and Travel Medicine at Mercy Medical Center in Baltimore, "is to be able to recognize the disease early enough."
    Zimring would know. Several years ago his wife felt fluish and came down with an oval-shaped rash. Zimring wasn’t sure what she had, but "knowing our backyard is loaded with ticks was enough," he says. He started his wife right away on one of the classic, effective antibiotics used to treat Lyme. When her medical tests came back, they proved him right. "I treated her for three weeks," he says, "and that was it. No problem."
    Unfortunately, not all Lyme patients recover so easily. And that’s what’s at the heart of the debate—some docs think patients who are treated inadequately can develop a chronic form of the disease, while others deny that it’s possible. Dr. Rafael Stricter, president of the International Lyme and Associated Diseases Society, believes in "chronic Lyme disease," and he says that in his clinical experience about 70 percent of patients with it get better if they’re treated long term with the same drugs used to treat early infection. But the doctors who made the new IDSA guidelines on treatment say there’s no such thing as chronic Lyme, because in most patients who complain of it, Borrelia isn’t detectable in the body. Dr. Gary Wormser, who chaired the IDSA panel, prefers the term "post-Lyme syndrome." "Treating that syndrome with high-dose antibiotics for months—as some physicians did before the new guidelines—can only hurt patients," he says. "It can give them gallstones and infections and lead to antibiotic resistance while not curing anything. The majority of patients treated for ’chronic Lyme’ do not have post-Lyme," he says, "and in fact never, ever had Lyme disease at all."
    This does not sit well with thousands of patients who believe they do have chronic Lyme and badly want antibiotic treatment for it. "The IDSA is basically saying to them, ’We’re right, you’re wrong, we don’t want to listen to you, just take some antidepressants and go away’," says Stricker. The IDSA is a highly respected group of doctors. But it’s facing formidable opposition, not just from Stricker’s group (and angry patients who’ve taken to Internet message boards) but also from the attorney general’s office in Connecticut, the state with the country’s highest incidence of Lyme disease. A.G. Richard Blumenthal has launched an investigation of the IDSA panel, looking into whether it ignored any research that would support long-term antibiotic treatment (the guidelines cite more than 400 studies). "Our question basically is whether the guidelines were formulated through a process that was proper, without self-interest or conflicts of interest," Blumenthal says, noting that some of the panel members have financial interests in treatments and vaccines. Blumenthal also worries that the new guidelines might be used by insurance companies looking to avoid paying for Lyme drugs. "The investigation is at an important juncture," he says. Meanwhile, Wormser is baffled. "How could the interests of the patient be served by treating with unnecessary and potentially dangerous therapies?" he says. "The guidelines represent the best that medical science has to offer." The question, then, is whether that’s good enough.
Which of the following statements is NOT true according to the chairperson of the IDSA panel?
选项 A、There is not a chronic form of Lyme disease.
B、Borrelia is not detectable in most patients who are said to have Lyme disease.
C、The majority of patients treated for ’chronic Lyme’ do not have Lyme disease .
D、Treating Lyme disease with high-dose antibiotics can lead to meningitis and heart problems.
答案D
解析 由第四段可知，领导小组的Wormser博士认为，没有一种慢性的Lyme病(A)，在大多数认为患有Lyme病的人体内就没有发现名为Borrelia的细菌(B)，而且大部分按照慢性Lyme病接受治疗的病人根本就没有得过所谓的Lyme病(C)。如果用大剂量的抗生素来治疗Lyme病，会使病人患上胆结石和感染等症状，并导致抗生素耐药，而不是脑膜炎或心脏病，故D为正确答案。
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