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  3. Personalized medicine has proved an elusive dream. Biotechnology companies have claimed that by matching a person’s genetic make

Personalized medicine has proved an elusive dream. Biotechnology companies have claimed that by matching a person’s genetic make

admin2014-06-25  71
问题     Personalized medicine has proved an elusive dream. Biotechnology companies have claimed that by matching a person’s genetic make-up with specialised treatments, they can tailor drugs to maximise benefits and minimise side effects. Alas, researchers have discovered that the link between a given person’s genetic make-up and specific diseases is much more complex than they had hoped. The tantalizing vision remains out of reach.
    A rare exception has been the success that Myriad Genetics, an American firm, has had with two genes called BRCA1 and BRCA2. Certain versions of these genes, it has been shown, are associated with a high risk of breast and ovarian cancer. The University of Utah has patented the genes and licenses them to Myriad. The firm uses that exclusivity to create expensive genetic tests for cancer risk which only it offers for sale.
    The BRCA patents have long frustrated medical researchers and legal activists. They claim that the firm’s grip on the two genes unlawfully stifles both innovation and basic science. Given the history of patent rulings in America, that has been a fringe argument—until now.
    On March 29th a federal district court in New York made a ruling that, taken at face value, turns America’s approach to the patent protection of genes on its head. The core of the case was this question: "Are isolated human genes and the comparison of their sequences patentable things?"
    Until now, the answer had been "Yes". But Robert Sweet, the presiding judge, disagreed. He ruled: "It is concluded that DNA’s existence in an ’isolated’ form alters neither this fundamental quality of DNA as it exists in the body nor the information it encodes. Therefore, the patents at issues directed to ’isolated DNA’ containing sequences found in nature are unsustainable as a matter of law and are deemed unpatentable subject matter. "
    As a rule, patents are not granted for rules of nature or naturally occurring phenomena, but the A-merican patent office has allowed genes to be patented if they are isolated and "purified. " Perhaps no longer, if this decision is upheld. It is clear that the judge also has the history books in mind. His ruling cites Stephen Breyer, a member of America’s Supreme Court, who argued that "sometimes too much patent protection can impede rather than ’promote the Progress of Science and useful Arts,’ the constitutional objective of patent and copyright protectioa "
    However, the majority of the Supreme Court did not agree with Justice Breyer. Dianne Nicol, a professor of law, observes that "this case turns on whether an isolated gene sequence has markedly different characteristics from a gene that occurs in the human body. The judge in this case has said it does not have different characteristics but it will be interesting to see if the higher courts agree with that. "
Myriad Genetics______.
选项 A、is the discoverer of the association between BRCA and cancer
B、is the patent holder of BRCA1 and BRCA2
C、has violated the law by selling expensive genetic tests
D、has aroused dissatisfaction among medical researchers
答案D
解析 第二段指出，Myriad Genetics公司取得了BRCA基因专利的独家使用权，且用此发明了昂贵的患癌风险基因检测。医学研究者认为Myriad Genetics公司所掌握的BRCA基因扼杀了创新和基础科学，即对Myriad Genetics公司大为不满，[D]选项正确。
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